Tetrahydrocannabinol (THC) is the only known intoxicating phytocannabinoid found in Marijuana that can alter the behavior, appetite, consciousness, mood, and perception of the user. During THC intoxication, brain imaging studies have shown increased blood flow to the prefrontal cortex region of the brain, which is responsible for decision-making, attention, motor skills, and more.
THC works to mimic the effects of anandamide and 2-AG. These are the neurotransmitters that are produced naturally by the human body and modulate sleeping, the perception of pain, eating habits, and countless other bodily functions.
The effects of THC include:
- Altered ENT functions
- Reduced aggression
The effect may last only a few hours, but the compound persists in the tissues for a longer time. Acute overdose may cause fatal conditions. The levels reach their peak through smoking.
THCA is a non-intoxicating and non-psychoactive cannabinoid compound that is found in either raw or live cannabis. It is the primary and most available constituent in raw, or fresh, cannabis, and gets converted to THC when dried and exposed to heat. This decarboxylation process is similar to the process of smoking or vaporizing the cannabis flower.
Every high-THC strain that has not yet undergone the process of decarboxylation will contain THCA. This compound is found to possess anti-inflammatory, antiproliferative, antiemetic, and antispasmodic properties. As such, studies show that it may be used to treat neurodegenerative diseases, arthritis, nausea, prostate cancer, appetite loss, muscle spasms, insomnia, and more.
Most people obtain their daily dose of THCA by adding raw cannabis greens to their diet. Raw cannabis buds and leaves are commonly consumed within:
- Blended salad dressings
- Raw salads
- Steamed greens
- Raw sauces
THCV (tetrahydrocannabivarin) is a minor and psychoactive compound found in cannabis plants. It’s obtained from the molecular precursor THCVa (tetrahydrocannabivarinic acid), and it’s found primarily in cannabis sativa strains.
CBGVa in the cannabis plant is broken down by enzymes, which produces THCVa. Thereafter, the THCVA gets decarboxylated when exposed to heat or sunlight it and produces THCV.
In terms of the receptor interaction, THCV acts as an antagonist at CB1 and a partial agonist at CB2. It is different from THC in that it has a propyl group, rather than a pentyl group. This variation influences varied benefits and uses of these compounds.
THCV is a psychoactive compound, and it possesses a lot of medicinal uses. It suppresses appetite, stimulates bone health, reduces panic and/or anxiety, helps with weight loss, and regulates blood sugar levels.
High levels of THCV cannot be attained only by cross culturing or other genetic methods as it varies too much from one harvest to another. Sometimes lab-tested strains may yield high levels of THCV as expected.
THCVa is a non-psychoactive cannabinoid found in cannabis plants. When cannabis plants get exposed to prolonged sunlight or heat, THCVa gets decarboxylated and produces Tetrahydrocannabivarin (THCV). High levels of THCVA may be found in in African sativa plants.
THCVa does not directly link to CB1 or CB2 receptors, so it has less therapeutic uses than other cannabinoids. That being said, research studies do suggest that THCVa could help reduce inflammation and pain. It also helps:
- Relieve symptoms of Alzheimer’s
- Treat prostate cancer, and fight cancer in general
- Control appetite
- With preventing overeating
- Reduce anxiety in those struggling with PTSD